June 20, 2005

Equetro can treat Bipolar I Disorder

The FDA has approved Equetro to treat patients who have acute manic and mixed episodes that result from Bipolar I disorder. "In a pooled analysis of placebo-controlled studies, patients taking EQUETRO who had been previously taking valproate or lithium (both with or without improvement of their symptoms) showed significant reduction in manic symptoms based on a standard measure of Young Mania Rating Scale" (Science Letter, 2005).

Equetro is a carbamazepine extended-release capsule. Hopefully this will have the same effect on those in the community with bipolar disorder as it did in the controlled study.

"Specifically, patients previously taking valproate had a reduction in their average YMRS scores by 10.8 on EQUETRO vs. 5.7 on placebo (p=3D0.04), and those previously treated with lithium had a reduction in their average YMRS scores by 11.6 on EQUETRO vs. 4.0 on placebo p=3D0.03). The analysis involved 115 patients from the two randomized, double blind placebo-controlled trials. There is a need for further clinical trials that are prospectively designed" (Science Letter, 2005).

Bipolar disorder is one of the most commonly diagnosed mental disorders and there are a variety of medications available to treat it. Lithium and valproate are two of the more popular kinds used.

For more information on Bipolar Disorder medications go to: http://www.moodswing.org/meds.html

For more information on Equetro go to: http://www.currentpsychiatry.com/article_pages.asp?AID=993&UID=

The Equetro company website can be found at: http://www.equetro.com/

The source of this article is the Science Letter via NewsRx.com & NewsRx.net


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