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January 13, 2006Pharma company announces agreement to develop treatment for bipolar disorderfiled under Bipolar Disorder Medications
In a Press/Marketing release, Memory Pharmaceuticals Corp. announced that it has entered into an agreement with The Stanley Medical Research Institute to develop MEM 1003, the company's neuronal L-type calcium channel modulator, as a treatment for bipolar disorder. Under the terms of the agreement, Memory Pharmaceuticals is eligible to receive up to $3.2 million from SMRI to fund the clinical development of MEM 1003 and will use these funds to support a Phase IIa trial of MEM 1003 in acute mania in bipolar disorder, which is scheduled to commence in the first half of 2006. Memory Pharmaceuticals also is currently conducting a Phase IIa clinical trial of MEM 1003 in Alzheimer disease. As part of the agreement, SMRI has purchased 440,367 newly issued shares of the company's common stock, at a price of $2.18 per share, constituting $960,000 of the total funding being provided to the company under the agreement. In addition, SMRI received a 5-year warrant for the purchase of up to 154,128 additional shares of common stock at an exercise price of $2.62 per share. The company will receive the remaining $2.24 million of funding upon the achievement of milestones related to the Phase IIa trial in bipolar disorder. These funds will be repayable to SMRI in the form of royalties, up to a specified maximum amount, on future sales of MEM 1003 for the treatment of bipolar disorder or schizophrenia. "Abnormal calcium levels are thought to be involved in conditions such as Alzheimer disease and bipolar disorder. MEM 1003 regulates calcium abnormalities and therefore has a solid rationale as a novel potential therapeutic for such disorders," said David A. Lowe, PhD, chief scientific officer of Memory Pharmaceuticals. "The Stanley Medical Research Institute collaborates with academic and corporate partners to advance the clinical development of promising treatments for bipolar disorder and schizophrenia," said Michael Knable, executive director of SMRI. "MEM 1003 represents a promising approach to the treatment of bipolar disorder, and we are pleased to be working with Memory Pharmaceuticals to take MEM 1003 into a proof-of-concept trial in bipolar disorder." MEM 1003 is a neuronal L-type calcium channel modulator that Memory Pharmaceuticals is developing for the treatment of Alzheimer disease and bipolar disorder. By blocking L-type calcium channels, MEM 1003 may regulate the flow of calcium and reestablish normal levels of calcium, which may correct or prevent the severe mood swings that characterize bipolar disorder. Memory Pharmaceuticals Corp. is a biopharmaceutical company. The Stanley Medical Research Institute funds research for severe mental illness.
Posted by at January 13, 2006 12:12 PM
More Information on Bipolar Disorder Medications
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yes i have bipolar1 distored and if you do any research on this i would like to be in the research it is a living hell to live with this and no one knows if they don't have it not only is it hard on us but also on our family because they can't understand it or us please help us so that we can live a normal life like the rest of the world and please don't forget me i'm on abilify,lamictal and xanzax i would really like to be a part of your study.thank you
Posted by: pam holder at April 12, 2006 12:07 PM
I ALSO HAVE BEEN DIAGNOSED WITH BIPOLAR 1. I HAVE BEEN ON SEVERAL MEDICATIONS SINCE 1996 AND STILL SUFFER WITH "EPISODES". I HAVE BEEN PRESCRIBED RISPERDAL, ABILIFY, LAMICTAL, LITHIUM CARBONATE, DESERYL (OTHERWISE KNOWN AS TRAZADONE), TOPAMAX, DEPAKOTE, PROZAC, WELLBUTRIN XL, AND SEREQUIL. ALTHOUGH NONE OF THE COMBINATIONS SEEMED TO HELP ME FOR VERY LONG AS I CYCLE SO FREQUENTLY. DEPAKOTE WAS PROBABLY THE BEST FOR THE MANIA BUT IT MADE ME GAIN ALOT OF WEIGHT AND MY HAIR FALL OUT. I WAS ALLERGIC TO LAMICTAL AND LITHIUM MADE ME EXTREMELY EXHAUSTED AND LATHARGIC AND FAT AS WELL. TOPAMAX WAS GOOD BUT I WAS MOVED UP TOO QUICKLY AND FOUND MYSELF SPACING OUT AND COMPLETELY OBLIVIOUS TO THINGS AROUND ME. THE ONLY GOOD THING IS THAT I LOST WEIGHT BECAUSE EVERYTHING THAT IS CARBONATED TASTES FLAT AND SO I CUT OUT POP. I WOULD REALLY LIKE TO SPEAK TO OTHER PEOPLE WHO HAVE THIS DISORDER TO SEE IF WHAT I FEEL LIKE BEING NONMEDICATED AT THIS TIME IS NORMAL. I'VE BEEN TO ENOUGH DOCTORS, I'D LIKE TO HEAR FROM SOMEONE WHO ACTUALLY SUFFERS FROM THIS CONDITION AND NOT SOMEONE WHO JUST STUDIES IT. THANK YOU
Posted by: andrea at October 5, 2006 3:39 PM
I was diagnosed with bi-polar 1 year ago after suffering my entire life with drug and alcohol addiction. After completing rehab my doctor placed me on Lamictal, Lithium,Serequil and Campral. Campral is a fairly new medication to curb cravings for drugs.I have found that after a year I still have episodes also. I haven't relapsed, but when I have one of these episodes it has been dificult not to. I honestly believe my by-polar is so severe that without my medication I will look for other ways to eliviate it.I would rather live with episodes than the way I was living.My idea is that maybe after a while some of these medications become less efective and a change may be needed.I see my doctor once a month and will ask his opinion.I have also gained some weight but still feel it is worth the cost.Living most of the time in a normal life is better than not at all.Hang in there it has to get better than what it was.
Posted by: Gloria Dupler at February 22, 2007 3:33 PM
hi i am 17 years old and caring for my dad who has schizophrenia. it is always a battle. i see him going through hell living his worst nighmares every day over and over again. i can only imagine how hard it is for him. i know its hard for me. i often feel as though im not doing enough. it hurts me so much when i see my father ny hero my world looking at me and not know wheter im on his side or against him. i wish there was some way i could take it all away from him.
Posted by: tania at March 29, 2007 6:10 PM