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Bipolar Disorder Daily News Blog: Antioxidants Being Studied as Treatment for Bipolar Disorder

August 20, 2007

Antioxidants Being Studied as Treatment for Bipolar Disorder

Clinical Psychiatry News featured an article outlining the research of Dr. Michael Berk, which was presented at the Seventh International Conference on Bipolar Disorder. Dr. Berk focuses on possible treatment of bipolar disorder and schizophrenia with antioxidants. The article is heavy on brain chemistry terms and theory, but still a good read about an exciting possible new treatment.

This research is motivated by the studies that suggest oxidative stress plays a role in both of the disorders and they even show deficits of certain antioxidant enzymes. Glutathione, specifically, acts as a defense against oxidative damage and is connected to the effectiveness of lithium and valproate (depakote) - the two most commonly prescribed drugs for treatment of bipolar disorder. Dr. Berk has focused his research on its possible use for treating bipolar disorder.

N-acetylcysteine (NAC), is a precursor of glutathione - which means its a compound that participates in the chemical reaction to produce glutathione, and its presence is necessary for glutathione to be created in the body. It's currently approved for treatment of overdoses of acetaminophen (Tylenol).

The article outlines Berk's small study on NAC and bipolar disorder, where they found that those in the participants receiving NAC showed significant improvements in a variety of areas; depression, mania, and overall functioning.

Some downsides of NAC are it takes very long to feel an effect, and the research supporting its use for bipolar disorder is preliminary. The drug however is available and FDA approved for other uses, which can speed up the process for researching its potential in the psychiatric field. Dr. Berk says, "Nonetheless, we are encouraged by these data, and we hope it will be a fruitful foundation for further study".

Read Full Article:
Antioxidants Studied for Bipolar Disorder, Schizophrenia
Clinical Psychiatry News By: Miriam Tucker

Comments

Antioxidants are agents from plant sources that prevent the breakdown or mutation of cells in the body. Astaxanthin, the active ingredient in Bioastin, has demonstrated exceptional capabilities as an antioxidant.

Posted by: bioastin at October 14, 2007 10:01 PM

Antioxidants are agents from plant sources that prevent the breakdown or mutation of cells in the body. Astaxanthin, the active ingredient in Bioastin, has demonstrated exceptional capabilities as an antioxidant.

Posted by: bioastin at October 14, 2007 10:02 PM

I was diagnosed with schizophrenia and later as schizoafective. Recently, I have been taking Tylenol due to prostate trouble. I read that N-Acetyl-Cysteine was the antidote to Tylenol, so I started taking NAC and L-Glutathione. After about 24 to 48 hours I felt a subjective improvement in my condition and noted that the medication and coffee induced mood changes have greatly moderated. I Googled on what I had observed and found this Australian study. In the next few months I plan to experiment with reduced neuroleptic dosage. I can be contacted via the USENET alt.support.schizophrenia newsgroup.

Posted by: Quiet Neighbor at December 16, 2007 12:24 PM

Dr. Strauss, who was the first person to run an ORAC evaluation on Acai berries and has found that Acai has the richest Antioxidant of any food in the world.

Posted by: Juicers at August 1, 2008 1:48 PM

Dr. Strauss, who was the first person to run an ORAC evaluation on Acai berries and has found that Acai has the richest Antioxidant of any food in the world.

Posted by: Juicers at August 1, 2008 1:49 PM

My granddaughter is fighting bi-polar. And she is also fighting a drug habit. I am looking for something in vitamins that may would help her. thanks for your help

Posted by: Joyce at August 3, 2008 4:20 PM

i have been trying a new
glutathione product called MAX GXL and have had terrific results better sleeping more alert and more energy if you would like to try it go to www.maxgxl.com/tjwellness and order it online i believe that it is very good for all types of disorders including bipolar and schizophrenia.

Posted by: terry at August 7, 2008 7:19 PM

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