Have you currently been prescribed medication and wondering what pain relievers can I take with ciprofloxacin?
It’s a common question, as ciprofloxacin is a powerful antibiotic used to treat a variety of bacterial infections, and pain relief may be necessary during treatment.
The good news is that there are some pain relievers that are generally safe to take with ciprofloxacin.
One pain reliever that is safe to take with ciprofloxacin is acetaminophen, also known as paracetamol.
This over-the-counter pain reliever is commonly used to treat mild to moderate pain and fever.
It works by blocking the production of prostaglandins, which are chemicals in the body that cause pain and inflammation.
Acetaminophen is generally considered safe when taken as directed, but it’s important to follow the recommended dosage guidelines and avoid taking more than the recommended amount.
Another pain reliever that may be safe to take with ciprofloxacin is ibuprofen.
However, there are some potential risks to taking these two medications together, so it’s important to talk to your doctor or pharmacist before combining them.
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by blocking the production of prostaglandins, similar to acetaminophen.
However, NSAIDs can increase the risk of side effects such as stomach bleeding and kidney problems, especially when taken for long periods of time or in high doses.
What Pain Relievers Can I Take With Ciprofloxacin
If you are taking ciprofloxacin, you may be wondering what pain relievers you can safely take.
The good news is that there are options available to you. However, it is important to note that not all pain relievers are safe to take with ciprofloxacin.
Here are some pain relievers that are generally safe to take with ciprofloxacin:

- Acetaminophen: This is a common pain reliever that is available over the counter.
- It is generally safe to take with ciprofloxacin, but make sure to follow the recommended dosage guidelines for both medications.
- Excessive use of acetaminophen can be harmful to your liver, and ciprofloxacin can also affect liver function.
- Opioids: If you have severe pain, your doctor may prescribe an opioid pain reliever such as codeine or oxycodone.
- These medications are generally safe to take with ciprofloxacin, but make sure to follow your doctor’s instructions carefully.
- Topical pain relievers: If you have pain in a specific area of your body, you may be able to use a topical pain reliever such as a cream or gel.
- These medications are generally safe to use with ciprofloxacin, but make sure to read the label carefully and follow the instructions.
It is important to note that some pain relievers are not safe to take with ciprofloxacin.
For example, non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen can increase the risk of side effects when taken with ciprofloxacin.
If you need to take an NSAID for pain relief, talk to your doctor first to make sure it is safe for you to do so.
In summary, there are several pain relievers that are generally safe to take with ciprofloxacin, including acetaminophen, opioids, and topical pain relievers.
However, it is important to follow the recommended dosage guidelines for both medications and to talk to your doctor before taking any new medications.
Pain Relievers To AvoidWith Ciprofloxacin
If you are taking Ciprofloxacin, it is important to know which pain relievers you should avoid.
Some pain relievers can interact with Ciprofloxacin and cause harmful side effects.
Here are some pain relievers you should avoid:
- NSAIDs: Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and aspirin can increase the risk of seizures and other central nervous system (CNS) side effects when taken with Ciprofloxacin.
- If you need a pain reliever, acetaminophen is a safer option.
- Opioids: While opioids such as codeine and hydrocodone are not known to interact with Ciprofloxacin, they can cause constipation and other gastrointestinal side effects.
- If you must take an opioid, make sure to drink plenty of fluids and eat a diet high in fiber.
- Muscle Relaxants: Muscle relaxants such as cyclobenzaprine and baclofen can increase the risk of seizures when taken with Ciprofloxacin.
- If you need a muscle relaxant, talk to your doctor about alternative options.
- Antidepressants: Some antidepressants such as amitriptyline and fluoxetine can interact with Ciprofloxacin and cause harmful side effects.
- If you are taking an antidepressant, talk to your doctor before taking Ciprofloxacin.
It is important to always talk to your doctor or pharmacist before taking any new medications, including pain relievers.
They can help you determine which medications are safe to take with Ciprofloxacin and which ones you should avoid.
Effects Of Combining Ciprofloxacin And Pain Relievers
When taking ciprofloxacin, it is important to be cautious when combining it with pain relievers.

Certain pain relievers can have adverse reactions and compromise the effectiveness of one or both drugs.
Here are some things to keep in mind when combining ciprofloxacin and pain relievers:
NSAIDs
Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, and aspirin should be avoided when taking ciprofloxacin.
These pain relievers can increase the risk of seizures and other central nervous system (CNS) side effects, such as hallucinations and psychosis.
Acetaminophen
Acetaminophen, also known as paracetamol, is a safe pain reliever to take with ciprofloxacin.
It does not have any known interactions with the antibiotic and is effective in reducing pain and fever.
Opioids
Opioids such as codeine, morphine, and oxycodone can be taken with ciprofloxacin, but caution should be exercised.
These pain relievers can cause CNS side effects and increase the risk of seizures.
Other Pain Relievers
Other pain relievers such as tramadol and gabapentin can also be taken with ciprofloxacin, but it is important to discuss this with your healthcare provider first.
These pain relievers can have interactions with other medications you may be taking or can cause adverse reactions.
In summary, when taking ciprofloxacin, it is important to avoid NSAIDs and use caution when combining opioids and other pain relievers.
Acetaminophen is a safe and effective pain reliever to take with ciprofloxacin.
Always consult with your healthcare provider before combining any medications.
Key Takeaways
When taking ciprofloxacin, it’s important to be mindful of the pain relievers you take.
Here are some key takeaways to keep in mind:
- Acetaminophen (Tylenol) is a safer option for pain relief while taking ciprofloxacin.
- Avoid taking nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve) unless directed by your healthcare provider.
- Always follow the recommended dosage guidelines for both medications to avoid potential liver damage.
- Ciprofloxacin may increase the blood levels of certain medicines, such as aminophylline, bedaquiline, bosutinib, and ciclosporin, which could increase the risk of their side effects.
- Do not take ciprofloxacin with milk, yogurt, or other dairy products as they can interfere with the absorption of the medication.
By following these guidelines, you can safely manage pain while taking ciprofloxacin.
Remember to always consult with your healthcare provider before taking any new medications.